![]() Platelets do not usually stick together unless there is a break in the endothelial lining of a blood vessel. Both types of thrombus can be dislodged from the vessel and become an embolus (blood clot moving through the bloodstream). Blood clots found in the veins are from platelet aggregation with fibrin that attaches to red blood cells. Arterial clots are usually made up of both white and red clots with the white clots (platelets) initiating the process, followed by fibrin formation and the trapping of red blood cells in the fibrin mesh. The formation of an arterial thrombus could be caused by blood stasis (decreased circulation), platelet aggregation on the blood vessel wall, or blood coagulation. Thrombosis is the formation of a clot in an arterial or venous vessel. Each of these three drug groups are discussed separately. ![]() The thrombolytics, popularly called clot busters, attack and dissolve blood clots that have already formed. The antiplatelets prevent platelet aggregation (clumping together of platelets to form a clot). The anticoagulants prevent the formation of clots that inhibit circulation. The three major groups of these drugs are (1) anticoagulants, (2) antiplatelets (antithrombotics), and (3) thrombolytics. ![]() Various drugs are used to maintain or restore circulation. Review Questions for the NCLEX® Examination.
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